What is the relationship between high uric acid and diabetes?

yourhealth 2020-8-3 12:27:42 disease view View comments

Patient asks: I have been suffering from diabetes for five years. I went to the hospital for a review some time ago. The doctor said I had high uric acid and was diagnosed with hyperuricemia. They are all metabolic diseases, is there any connection?

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Answer: Uric acid metabolism and sugar metabolism are a pair of "difficult brothers". Studies at home and abroad have shown that hyperuricemia is closely related to the damage of multiple target organs. The deposition of urate in the joints will cause gouty arthritis and eventually joint deformation; the deposition in the kidneys will lead to gouty nephropathy and uric acid stones, and even eventually cause uremia; in addition, urate crystals can cause irritation Blood vessel walls lead to atherosclerosis, which will eventually lead to coronary heart disease, hypertension, stroke, etc.; when urate is deposited in the pancreatic islets, it can cause damage to pancreatic β-cell function, induce and aggravate insulin resistance, cause glucose metabolism disorders, and ultimately Lead to the occurrence of diabetes. Correlation analysis shows that for every 1 mg/dL increase in blood uric acid, the relative risk of diabetes increases by 65%.

25% of diabetic patients have hyperuricemia. It may be caused by abnormal renal uric acid excretion, leading to increased blood uric acid production and increased purine catabolism. In addition, hyperuricemia can also aggravate the metabolic disorders of type 2 diabetes patients, predict and aggravate the development of atherosclerosis, and increase the occurrence of cardiovascular and cerebrovascular events.

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